Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 6-10

The 25-anniversary of the Institute of Internal Medicine of SB RAMS

Nikitin Yu.P.

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 11-21

Longevity as a model for study of ageing

Shabalin A.V., Voevoda M.I., Chernykh N.I., Pentegova V.A., Ragino Yu.I., Ivanova M.V., Romashchenko A.G., Maksimov V.N., Kulikov I.V., Schakhtschneider E.V.

Review of literature and own results on the problem of longevity in Siberia is presented. Data of some clinical, molecular-genetic and biochemical aspects of longevity in Western Siberia are studied. Comparative evaluation of longevity phenomenon and human ageing has been carried out on the model of study of cardiovascular system status in elderly population and long-livers of Novosibirsk.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 22-30

Nutrition and health of population in Siberia: results of a 20-year epidemiological researches

Simonova G.I., Nikitin Yu.P., Bragina O.M., Shcherbakova L.V., Malyutina S.K.

 

This work presents the results of a 20-year epidemiological researches regarding the analysis of actual nutrition of urban population at 25-69 aged in Siberia and its connection with the conventional CHD risk factors of and other chronic non-communicable diseases. Also there was an estimation of food value imbalance and fat, protein and carbohydrate components imbalance in 24-hours food allowance in adult population at 25-64 aged in Novosibirsk and their role in forming of primary CHD risk factors, tendencies of all-cause and CVD mortality and prediction of death-rate within the next few years. And also, a scientific and practical value of researches of the Institute of Internal Medicine in the field of the nutrition epidemiology in development of scientifically proved programs of CNCD prevention in Siberian region was given.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 31-34

Results of epidemiological monitoring of stroke in Siberia (WHO program «MONICA»)

Shishkin S.V., Simonova G.I., Pilipenko P.I.

The analysis of results of the WHO «MONICA» program according to epidemiological monitoring of stroke in 14 populations from 9 countries of Europe and Asia (1982-1995) testifies existence of significant interpopulation distinctions. The highest parameters of morbidity at stroke were in Novosibirsk: 449 (403, 500) and 391 (352, 433) on 100000 men and women, accordingly. Frequency rate of distinctions with the countries with low parameters of morbidity has made 3,7 and 6,6 times in men and women, accordingly. In the majority of the examined populations the woman had higher stroke case-fatality, than men though distinctions were not statistically authentic. Death rate from stroke in Novosibirsk has reached 160 cases on 100000 population in one year in men and 82 on 100000 in women, having exceeded, accordingly, in 6,2 and 4,6 times parameters of death rate in populations of the countries of Northern Europe.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 35-39

Ischemic heart disease and psychosocial factors

Gafarov V.V., Gagulin I.V., Gromova E.A.

Aim: To study correlations between personal anxiety as one of the leading psychosocial factors and ischemic heart disease. Material and methods: The third screening (1994) of the program MONICA and subprogram MOPSY-MONICA-psychosocial covered a random representative sample of males at the age of 25-64 years living in Novosibirsk. The response was 82% (657 responders, mean age 44,3±0,4 years). Statistical analysis was based on the SPSS-10 software package. Results: Prevalence of personal anxiety as an indication of social stress in a male population of 25-64-years old is very high especially in young age groups. Personal anxiety is maximum among persons with elementary education and workers. Persons with personal anxiety experience strong stress in job and in family settings. Ischemic heart disease rate is higher among personal anxiety patients. High personal anxiety is often associated with depression, high hostility, cachexia, sleep problems, low social support. Personal anxiety patients have a negative opinion of their health but their attempts to improve it are insufficient. The proportion of those who quit smoking, reduce the number of cigarettes, keep diet, restrict physical activity grow in PA persons. Conclusion: Personal anxiety is prevalent among male population, especially, in young persons. A PA level correlates with social status. Ischemic heart disease occurs more frequently in personal anxiety persons. High personal anxiety often associates with other psychosocial factors.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 40-51

Cardiovascular risk factors among adolescents in Novosibirsk: prevalence and long-term trends

Denisova D.V., Zayjyalova L.G.

 

Hyperlipidemia, arterial hypertension, cigarette smoking, overweight and physical inactivity are known as risk factors for coronary artery disease. Control of the factors since adolescence may reduce cardiovascular morbidity and mortality in adulthood. Purpose of the study was to assess prevalence and trends of the cardiovascular risk factors among adolescent population in Novosibirsk during the reforms (1989-2003). Methods: Four cross-sectional surveys of representative samples of school children 14-17 aged in 1989 (656), in 1994 (620), in 1999 (626) and in 2003 (667) were carried out. Body mass index (BMI, kg/m2), systolic (SBP) and diastolic blood pressure (DBP), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. Self-report of smoking (1 cig/week and more) and physical inactivity (2 h/week and less) was obtained. Results: According to NCEP-peds criteria (1992), prevalence of high TC (200 mg/dl and more) during the period (1989-2003) significantly decreased from 22% to 8% (P < 0,01) in males and from 32% to 17% (P < 0,05) in females. The similar trends were found in prevalence of high LDL-C (130 mg/dl and more) and low HDL-C (<40 mg/dl). LDL-C/HDL-C ratio decreased from 2,39 to 1,74 in boys and from 2,10 to 1,75 in girls (P < 0,01). According to the 4th Report of the NHBPEP Working Group (2004), prevalence of arterial hypertension during the period was high in both gender groups with decreasing from 58% to 36% (P < 0,01) in boys and from 31% to 23% in girls; arterial hypertension also decreased from 12% to 6% in boys (P < 0,05) and from 16% to 5% in girls (P<0,05). Frequencies of overweight (BMI ≥ 85th percentile from CDC-2000) in 1989-1999 decreased in 3 times, but increased by 2003 again. Cigarette smoking rate in boys decreased from 45% in 1989 to 27% in 2003; at the same time the prevalence of girls’ smoking increased from 19 to 27%, in 2003 the smoking rate in boys and girls was equal (27%). Physical inactivity rate was high during the period in boys (49-55%) and girls (83-73%). Conclusion: The data obtained indicate on similar trends to reduction in classical CVD risk factors, and life style changes among Siberian adolescents during the period of the socioeconomic reforms in Russia.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 52-55

Life quality in population of Siberia (population study)

Simonova G.I., Bogatyrev S.N., Gorbunova O.G., Shcherbakova L.V

 

Indices of life quality were studied in random sample of 2156 men and 2769 women 45-69 aged. Russian version of SF-36 was used. Quality of life was significantly higher in men than in women according to all scales. The difference was 30% on role physical, 25% on role emotional, 17% on vitality and bodily pain, 15% on physical function, 14% on mental health, 11% on social function and 10% on general health. Indices of life quality declined from 45 to 69 years both in men and in women except social function. The biggest decline was observed in persons 65-69 aged. The highest indices of life quality in population of Novosibirsk were observed on physical function and social function while the lowest — on general health. Indices Indices of life quality in population of Novosibirsk were lower than in Canada, England and New Zealand in the same age groups but were comparable with quality of life in St-Petersburg.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 56-62

Family history and its relation to CVD in male population of Novosibirsk

Voevoda M.I., Maksimov V.N., Mayutina S.K.

Using the standard epidemiological methods, prevalence of family history on ÑVD and its association with IHD and AH in male population 25-64 aged ,inhabitants of Novosibirsk has been studied. It is established, that prevalence of family history on IHD in males — 26.8 %, on an arterial hypertension — 38.7 % Association family history on ÑVD with presence of disease at the proband was estimated with the help univariant and multivariant logistic regression analysis. Increase risk to have AH: increase of BMI, age, education, high triglycerides level, high total cholesterol, smoking, an arterial hypertension at relatives of the first degree of relationship, an insult, heart attack at the father. Increase risk to have IHD: increase of age, of BMI, and also presence of the arterial hypertension, family history on IHD, an arterial hypertension at sisters, parents. Family history on CVD in a population is one of independent risk factors of development IHD and AH, due to significant prevalence and simplicity of revealing, it can be used as one of criteria for formation of groups of the increased risk with the purpose of carrying out of initial preventive maintenance.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 63-66

Microcirculatory endothelial-  dependent vascular reactivity and main risk factors

Nikolaev K.Yu., Gicheva I.M., Lifshits G.I., Nikolaeva A.A.

This review is dedicated to influence of main risk factors such as age, heredity, smoking, arterial hypertension, dyslipidemia, obesity and diabetes mellitus II type on microcirculatory endothelial-dependent vascular reactivity.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 67-73

Atherosclerosis and oxidation. new methods to evaluate protein oxidative modification

Ragino Yu.I., Baum V.A., Polonskaya Ya.V., Voevoda M.I., Nikitin Yu.P.

Oxidative stress is one of the key pathogenic components, resulting in initialization of origin and development of atherosclerosis. Not only lipid peroxidation (LPO) processes but also protein oxidation processes are integral components of oxidative stress. In this study the new methods to evaluate oxidative modification of plasma fibrinogen and of apolipoproteins (apo-LP) of low density lipoproteins (LDL) were worked out. Clinical approbation of the new methods was carrying out using of plasma of 112 men of 39-65 aged, included 43 men with coronary heart disease (CHD) and myocardial infarction (MI) in anamnesis last year, 19 men with subacute MI and 50 men without CHD similar to age. Oxidative modification of plasma fibrinogen was higher on the 38% and 66%, respectively, in men with CHD and subacute MI in comparison with men without CHD. Oxidative modification of apo-LP of LDL was higher 1,3-fold in men with CHD and subacute MI in comparison with men without CHD. Positive correlation between of oxidative fibrinogen and blood LPO products, negative correlations of oxidative fibrinogen with blood level of NO metabolites and of oxidative apo-LP of LDL with blood level of NO metabolites were revealed. Correlation relationship between oxidized lipid component and oxidized apolipoproteins component of LDL particles was not found.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 74-79

Dyspeptic syndrome: from epidemiological studies to cancer prevention

Kurilovich S.A., Reshetnikov O.V., Krotov S.A., Krotova V.A., Pylinkova E.D.

Cross-sectional epidemiological study (including 1022 persons of 25-69 aged and 596 children and adolescent , 5-17 aged  including 59 families) was performed. Prevalence of Helicobacter pylori infection, CagA strain of HP and Pepsinogen I and Gastrin-17 level were estimated by IFA (test-systems «Pyloriset-New EIA«, «Gasrtoset PGI», «GastroPanel» and «HelicoBest Antibody» were used). Dyspeptic symptoms were revealed by standard questionnaire. Prevalence of HP-infection was very high in all adult population ((70-85%), CagA strains of HP were found near 60% in all aged respondents. CagA-positivity was associated with dispeptic syndrome, acid-related symptoms and pepsinogen I level. The deficient of sensibility of European test-system and preference of Siberian test-system for diagnostic HP-seroprevalence  was established. Prevalence of dyspeptic syndrome and its risk factors was similar in adult and adolescent. Prevalence of dyspeptic syndrome, CagA strains of HP, atrophic  gastritis were higher, but Pepsinogen I level and acid-related symptoms were lower in Yakutia , than in Novosibirsk(30,8% vs 22%, 84% vs 56,4%, 51,8 vs 94,4% and 9,6% vs 15,4%). We postulated, that noninvasive methods were very useful for diagnostic of atrophic gastritis («carcinoma-like» phenotype) and forming risk-groups of noncardiac carcinoma in general populations. These groups were needed in cancerprevention. HP-eradication is a real method for this.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 80-87

Apolipoprotein E polymorphism, gallstone disease and pancreatitis

Grigorjeva I.N., Nikitenko T.M., Romanova T.I., Osipenko M.F., Egoshina M.A., Sedinina E.V., Venzhina YuYu., Schakhtschneider E.V., Kulikov I.V., Maksimov V. N., Usov S.A., Mironenko T.V., Potapova T.A., Danilcheva T.V., Ivanova M.V., Romashchenko A.G., Malyutina S.K., Voevoda M.I.

In this article our experience in the researching of APOE polymorphism, lipid metabolism disorders and litogenicity bile indices in Gallstone disease (GSD) and pancreatitis patients is presented. We proved that APOE polymorphism in women, in women with GSD, and in women with verified cholesterol GSD was the same. The frequency of ÀÐÎÅ genotypes and alleles in the patients with acute and chronic pancreatitis significantly wasn’t differ from the population data. However, frequency of genotype APOE E3/E4 in the patients with pancreatitis in 2,2 times exceeds those in the controls (p>0,05). The genotype APOE E3/E4 was met significantly more often in patients with acute pancreatitis, than in patients with chronic pancreatitis. APOÅ4 allele in patients with acute pancreatitis was met much more often, than in patients with chronic pancreatitis (p<0,05). Associations between APOE polymorphism and blood lipid levels in women with GSD haven’t revealed. It is shown, that the greatest cholesterol concentration in bile is marked in women with cholesterol GSD with APO E2/E4 or APO E3/E4 genotypes.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 88-92

Arterial hypertension and risk of cardiovascular mortality in an urban siberian population

Simonova G.I., Nikitin Yu.P., Glushanina O.M., Malyutina S.K., Scherbakova L.V.

 

The aim of research was to study prevalence of arterial hypertension (AH) and frequencies of various levels arterial blood of pressure in urban siberian population on the basis of three cross-sectional researches during 1984-1995. The estimation of risk levels of cardiovascular mortality by a scale SCORE. The basis about mortality from cardiovascular diseases are received on the materials of 10-year’s prospective cohort study depending on levels of BP. Within the framework of the WHO project MONICA the random sample was formed of 4869 men and 4931 women 25-64 aged from unorganized population of two districts of Novosibirsk with total population about 300 000 men. The prevalence of AH by criteria on European Society of Hypertension — European Society of Cardiology guidelines for the management of AH (2004) has made 48 %. The frequency of AH was higher in men, than in women (49 % and 47 % accordingly). In the age group 55-64 years old AH was more often was registered in women. 23 % of men in Novosibirsk population have the 1-st degree AH, the optimum values of BP are stated in 22 % of women. At the persons of both sexes the prevalence of isolated diastolic AH is high, but in men it is registered more often, than in women (17 % against 12 %). Among the men 45-64 years of age the high ten years’ risk of cardiovascular mortality on a SCORE scale (> 5 %) at the second and the third degrees of AH and at isolated diastolic AH has been registered at 1.9-2,5 times more often, than at normal and high normal levels of BP. In a female population high cardiovascular risk was also more often revealed at more levels of BP, but, in comparison with male population, frequency of high cardiovascular risk was much lower.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 93-99

Reproducibility, predictive importance and pharmacological dynamics of QT-RR-indices on electrocardiogram in patients with arterial hypertension (clinical population study)

Kuznetsov À.À., Shabalina V.N., Lifshits G.I., Lapitskaya I.V., Malyutina S.K.

 

Within the frames of the WHO «MONICA» project in Novosibirsk standard epidemiological methods, three representative samples of the general male population 25-64 aged (2167 persons) have been examined. On electrocardiogram values of duration and a dispersion of QT interval, frequency and variability of heart rhythm were defined. In addition, there studied influence of a single doze of captopril and propranolol in the basic group (17 persons) as compared to «placebo» in the control (18 persons) patients with high normal arterial blood pressure and arterial hypertension. In men with arterial hypertension, delay and increase dispersion ventricular repolarization, and also decrease in heart rate variability, irrespective of other controllable factors have raised the risk of cardiovascular death. Combined definition of blood pressure, heart rate and duration of interval QTc in men with high normal arterial blood pressure and arterial hypertension possesses the high reproducibility allowing objectively to estimate pharmacological effects.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 100-107

A social gradient of lipid profile and anthropometrical indices among new coming population of Yakutia

Êylbanova E.S., Shcherbakova L.V., Ìàlyutina S.Ê.

 

The purpose of study: To assess a social gradient of blood lipids and anthropometrical indices in new coming population of Yakutia. Material and methods. The profile of CVD risk factors in Udachny, Yakutia was studied. The sample of new coming inhabitants (mainly Russians) 45-69 aged was examined (341 men and women in total). The program of the study included standard epidemiological survey. An estimation of the social status was carried out with help of standardized questionnaires (education level, marital status, level of deprivation, reaction to economic and social changes after 1989 were estimated). The estimates were adjusted for age. Results. In the studied sample of new coming population of Yakutia 45-69 aged we revealed gradient of BMI, WHR and blood lipids values by educational level, marital status, level of deprivation and reaction to socioeconomic changes 1989. The level of lipids and metabolic parameters in the studied Yakutia sample demonstrate a social gradient unfavorable characteristics associate with low educational level, unmarried status and high level of deprivation.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 108-115

31P NMR spectroscopy of erythrocytes and liver fibrosis: pilot investigation

Kruchinina M.V., Kurilovich S.A., Parulikova M.V., Gromov A.A., Shakirov M.M.

 

Under supervision there were 19 men in the age of from 35 till 60 years with different stages of diffusion liver diseases. Liver biopsy was carried out to evaluate the degree of liver fibrosis. To all men there were carried out clinical, biochemical, instrumental and morphological inspections. In view of the morphological data patients were divided into two groups — the first group with the light and moderate liver fibrosis (F1-F2); the second — with the severe liver fibrosis and liver cirrhosis (F3-F4). There was a control group — 33 healthy men without liver (F0) and heart diseases. The studies were performed with suspensions of erythrocytes using the 31P NMR spectroscopy (DRX 500, Bruker, Germany). Is experimentally established: area of peaks from glucoso-6-phosphates,AMF, IMF, pyrophosphates, 2,3-DFG of erythrocytes are increased and area of peaks from inorganic phosphates, phosphocreatin, α-, β- and γ-ATP, UTF, Hb-, Mg-ATP are decreased with growing the degree of liver fibrosis. These 31P NMR parameters of erythrocytes can be used as additional characteristics of liver fibrosis degree with a enough high prognostic value (92,3%).

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 116-120

Some parameters of human health (microelement blood structure)

Zhuravskaya E.Ya., Kutzenogy K.P., Chankina O.V., Savchenko T.I., Andryushina N.A., Gyrgolkay L.A.

 

Microelement blood composition in “apparently healthy” men and women in Novosibirsk was investigated using SRXRF method. In men 34-54 years of age there was revealed K, Ge, Se, Rb deficiency and Pb, Ni, Co, Cr were found in surplus. In women 30-50 years of age K, Ca, Fe, Zn, Se deficiency was found, and there was no a surplus of heavy metals, Pb and Hg. Men in subsample aged 45-69 had a deficiency of K, Zn, Se and a surplus of Ti, Cr, Ni, Cu, Rb, Pb.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 121-123

Imbalance of chemical elements in ethiology of Alzheimer’s disease

Sukhanov A.V., Zhuravskay E.I., Gyrgolkau L.A., Kutzenogy K.P., Chankina O.V.

 

The aim of this study is to measure blood level of some chemical elements in patients with Alzheimer’s disease. Patients with Alzheimer’s disease (mean age 68,3±6,2) were investigated. The SRXRF method for measure of 25 chemical elements was applied. Combined deficit of 5-7 chemical elements in Alzheimer’s disease patients were revealed. Together with earlier well-known aluminum concentration level increases, the exceed concentrations of bromine, strontium and rubidium were revealed. These chemical elements imbalance supports the considerable role of trace elements in Alzheimer’s disease pathogenesis and opens the novel ways to Alzheimer’s disease prevention.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 124-131

Organizational-functional model of primary prevention of noncommunicable diseases in railway workers

Kudelkina N.A., Shchetinin A.N.

 

The methodical and methodological approaches being developed by the authors of the paper are aimed at reforming the not very effective existing model of railway health system under the new economic conditions. This is to be achieved by establishing the system of primary prevention to strengthen and preserve professional health of railway workers, first of all, of those engaged in key railway jobs, such as members of locomotive brigades. The system is to be based upon regular and permanent preventive complex use of health restoring techniques which are being developed taking into account occupational labor conditions, peculiarities of individual health, life style and morbidity structure. The results obtained during the prevention work within the frame of a new structural organization of outpatient and polyclinic departments in the railway health system have shown significant improvement in health and life quality of railway workers.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 132-134

Transformation of personality in the North and and its connection with psychosomatic pathology

Chukhrova M.G., Khoroshilova L.S.

 

It has been shown that the high level of alexithymia is one of the leading factors of the disadaptive and pathological disturbances formation risk especially in cardiovascular, immune and nervous systems, organs of digestion, liver and urinary system. There revealed that in patients, who suffer from psychosomatic pathology, alexithymia appeared in 61%. The neurophysiological analysis of the brain hemispheres interaction in alexithymia patients is carried out. The special features of the vocal activity lateralization revealed with neurophysiological test. There revealed that alexithymia patients have the disturbance of the hemispheric activation balance.

 

YOUNG SCIENTISTS

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 135-140

Family aspects of hypercholesterolemia in adolescents

Burakova S.V.

 

Objectives: To assess prevalence and relationships of hypercholesterolemia in adolescents and their parents. Design and methods: cross-sectional survey of representative samples of school children 14-17 aged was carried out. The group of adolescents with hypercholesterolemia (total cholesterol >=180 mg/dl, 4,6 mmol/l) and their parents were examined. 100 families (97 mothers, 38 fathers, 72 girls, 28 boys) were included into the analysis The program of the inquiry in adolescents and parents included questioning about smoking, physical activity, measuring systolic and diastolic blood pressure, anthropometry (height, weight), investigating levels of total cholesterol in serum, cholesterol of high-density lipoproteins (HDL-C), triglycerides. Results: Fathers of adolescents with hypercholesterolemia had  more great frequency of it (68%) than in population (46%). In the subgroup of adolescents with more high levels of total cholesterol and LDL-C both mothers and fathers also had more high levels of those indices than in the subgroup of adolescents with less values of hypercholesterolemia. Family relationships of hypercholesterolemia indicates necessity of preventive actions at a family level.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 141-142

Frequency of detection of del f508 mutation of mucovisdidosis gene in population of Novosibirsk and its relation with different pathologies

Gurina I.V.

 

The purpose of our work was to study optronally the frequency of the mutation del F 508 in population of Novosibirsk 45-69 aged examined in the frame of International project HAPIEE and characteristic of the various pathology in patients having this mutation. The total sample investigated composed 9397, men and women, which were subjected to molecule-genetic investigation for mutation del F508. This mutation was found in persons (1.15 %) among the heterozygous carriers of the mutation the frequency of chronic bronchitis or COPD and cholelithiasis composed 24,4% and 11,9%, respectively, that suggests the damage of exocrine glands as clinical manifestations of the mild from of the cystic fibrosis and the influence of genetic factors on the phenotype.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 143-145

Social picture of parent with severe out-hospital pneumonia in the North

Egorova N.E.

 

Frequency and lethal outcomes in patients with severe community-acquired pneumonia were increasing during last years everywhere. In Yakutia, and in the other Northern regions, the problem of pneumonia is quite relevant, since according to the climate conditions, the republic is considered as a high-extreme region. Case histories of 77 patients with severe pneumonia were analyzed. It have been discovered that death rate was higher in working men, aboriginal and alien living in Yakutia more than 3 years. The highest death rates have been revealed during first 72 hours of hospitalization.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 146-150

Essential hypertension and a 24-hour profile of arterial blood pressure in pre- and menopausal women

Kravchenko O.V.

 

The aim of the study was to assess a 24-hour blood pressure in women inclimacterial period and to compare the levels of blood pressure (BP) and frequency of arterial hypertension (AH) during a 24-hour BP monitoring and office measurements. 153 women, both reproductive, menopausal and postmenopausal were examined and included into two age groups: women in 40 — 49-years of old were the first group and the second group consisted women at the age 50 — 59. The parameters of a 24-hour BP profile were increased in women of the second group. Besides, the frequency of AH was higher in postmenopausal women independently of biological age.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 151-153

Daily rhythm determinants and variability of arterial blood pressure and pulse in population of Novosibirsk

Krupa T.M., Pello E.V.

 

As material for the present work data European study EPOGH have served. With the response in 67% sample of inhabitants of October area of Novosibirsk (304 persons 18-82 aged has been surveyed random family sample: 131 men and 173 women).  An ambulatory 24-hour registration of arterial pressure and pulse was conducted by means of monitors “ SpaceLabs 90207 “. For editing daily records used modified criteria Casadei. Results of research have shown, that the important parameters — the daily rhythm and variability of arterial pressure and pulse in population of Novosibirsk are determined by such factors as age, a sex, lipid level and left ventricular electric potential.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 154-159

Phenotypic signs of HFE genotype in parents with chronic hepatitis with iron excess syndrome

Kulagina E.A.

 

Objective: The aim of the study was to investigate the frequencies of HFE gene mutant alleles and its association with Fe-overload syndrome (FOS) in HCV — patients. Materials and methods: 70 patients with HCV were examined including measurement of serum Fe, ferritin, liver enzymes, glucose intolerance test and HFE polymorphism. Results: In 24% of HCV-patients FOS was found, in this group mutant alleles of HFE gene were detected in 71%. Frequency of carbohydrate metabolism disturbances (CMD) in HCV-patients with FOS was higher, then in patients without FOS (41% vs 8%). C282Y allele was associated with highest frequency of CMD (57% vs 11%). Conclusion: In studied sample polymorphism of HFE gene (C282Y or H63D) associated with Fe-overload and carbohydrate metabolism disturbances in HCV-patients.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 160-163

Indices of bile lithogenicity and blood serum lipids, inflammation of gall-bladder mucous tunic in women with cholesterol cholelithiasis

Nikitenko T.M.

 

Within the framework of clinical research 90 women with cholesterol gallstone disease (CH GSD) are surveyed. Inflammatory infiltration was revealed at 96,6% of the patients: weak infiltration of gallbladder mucosa was determined in 24 women (27,6%), moderate infiltration — at 58 women (66,7%), strong inflammation infiltration was observed in 5 women (5,7%). Elevated serum cholesterol was revealed at the weak, moderate and strong inflammation in patients with CH GSD, however it was not significant difference between these three groups. The serum cholesterol level in the patients with CH GSD, who have not gallbladder inflammation, was normal. We proved, that serum cholesterol level in the patients with CH GSD with moderate inflammation (5,5±0,1 mmol/l) was significantly higher than in patients, who have not gallbladder inflammation (4,6±0,3 mmol/l, p<0,01). The indices of bile lithogenicity were not associated with gallbladder mucosa inflammation at the women with CH GSD.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 164-167

The role of Str.pneumonia in ethiology of out-hospital pneumonia and its sensitivity to antibacterial drugs

Ponikarovskaya L.A.

The data confirming the ethiological structure of community-acquired pneumonias (CAP) are quite relevant for planning initial empirical antimicrobial treatment, as 80% of patients suffering from pneumonia receive outpatient treatment. According to the number of Russian and foreign researches, the contribution of Str. Pneumoniae in the etiological spectrum of CAP is of an ambiguous nature. An important problem now is the fact that drug — resistance strains to penicillin and erythromycin are spread among pneumococcus. The etiological spectrum of CAP was studied at the out-patient stage, and its approximate susceptibility to antibiotics of penicillin series and macrolides was determined by means of the screening and disco-diffuse method. Str. Pneumoniae continues to be the leading pathogen in the etiological structure of CAP — 44,8% (χ2=158,034, df=8, ð<0,0001). It retains high susceptibility to antibiotics of penicillin series — 82,4% of strains (to oxacilline).

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 168-171

Effectiveness of screening  investigation method for detection of disorders of airway conductance

Strabykina P.E.

 

Chronic obstructive pulmonary disease is one of the most widespread diseases. In Russia CO P D takes the 1-st place (55 %) in the structure of respiratory system diseases, significantly outstripping a bronchial asthma (19 %) and pneumonia (14 %). In order to prevalence among noncommunicable diseases it takes the second place in the world, and the 4-5 th place in structure of lethal outcomes among persons elder than 45 years. The screening examination of the open population of the Oktyabrsky district , Novosibirsk was carried out in 2004-2005 in bounds of the international project <HAPIEE> (determinants of cardiovascular diseases in the East Europe : multicentre cohort study, UKA). In total 1490 persons aged 39 to 73 years: 773 men (51,88 %), 717 women (48,12 %) were investigated. Results of the study have shown: prevalence of the airflow obstruction syndrome in a popula- tion is 6,2 %: 9,7 % among men, 2,5 % among women. More than half of 61, 3 % of them didn`t know about the respiratory conductance disorders and disease, basically these were persons with slight degree of airflow obstruction. Thus, the spirography has shown the high efficiency as a method of detection of bronchial conductance disorders and allowed to recognize the group of persons with initial attributes of airflow obstruction, which is the most perspective concerning the forecast and treatment of the COPD .

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 172-174

Specific features of external respiration function in parents with pulmonary sarcoidosis

Turlai E.A.

 

The syndrome of airway obstruction is typical for Sarcoidosis. More often small airways are involved. The heaviness of airway obstruction are not in a correlation with X-ray stage of Sarcoidosis and depends on the mechanisms of airway obstruction. Variations, found in this research, would tend to be normalized during treatment of the disease.

MISCELLANEA

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 175-181

Frequency of non-Hodgkin’s lymphoma in Novosibirsk, Novosibirsk region and other cities of Siberian federal area

Koyinev I.Â., Pospelova T.I., Ageeva T.A., Loseva M.I., Voropaeva E.N., Djyachkova N.Yu.

 

There were examined 764 patients,living in the Siberian federal area and in Kazakhstan and suffering from non-Hodgkin’s lymphoma. For the first time in this territory there thoroughly studied the structure and the morbidity of the basic clinico-immunomorphological variants of the lymphomas in accordance with the WHO classification. It was shown the role of the immunomorphological diagnostics with the utilization of the wide monoclonal antibodies panel. There were confirmed the key value of research of the totality of clinical, morphological, immunphenotypic and genetic attributes for lymphoma’s variant verification, that is an obligatory condition for the adequate program’s selection of the treatment and the outcome of the disease.

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 182-187

Reparation regeneration at transplantation of osis transplants with implants in the experiment

Sysolyatin P.G., Zhelezny P.A., Zhelezny S.P., Zaidman A.M.

 

In 16 animals, created defect of lower jaw   was substituted by autotransplants (replants) in which inculcated three types of implants : titanic cylindrical smooth and screws, and pores of NiTi. The conducted morphological researches in terms to 1 year showed that the implants did not render negative influence on substitution of transplant by a new bone. The valuable forming of organotypicale bone regeneration can be observed. On a border bone- implant of process reparation regeneration and integration of implant depended on surface of the last. Round implants with permeable porosity, forming of mature bone went along with the germination in its pores of NiTi.

 

ANNIVERSARY

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 188-189

Kuznetsov Vadim Anatoljevich (towards 50-years from the day of birth)

 

Bull. Sib. otd. Ross. akad. med. nauk. — 2006. — ¹4. — P. 190-191

Heroes of the day (2007)